Chromosome-level genome of Schistosoma haematobium underpins genome-wide explorations of molecular variation

AJ Stroehlein; PK Korhonen; V Vern Lee; SA Ralph; M Mentink-Kane; H You; DP McManus; LAT Tchuente; J Russell Stothard; P Kaur; O Dudchenko; EL Aiden; B Yang; H Yang; AM Emery; BL Webster; PJ Brindley; D Rollinson; BCH Chang; RB Gasser; ND Young

Journal article

Chromosome-level genome of Schistosoma haematobium underpins genome-wide explorations of molecular variation

AJ Stroehlein, PK Korhonen, V Vern Lee, SA Ralph, M Mentink-Kane, H You, DP McManus, LAT Tchuente, J Russell Stothard, P Kaur, O Dudchenko, EL Aiden, B Yang, H Yang, AM Emery, BL Webster, PJ Brindley, D Rollinson, BCH Chang, RB Gasser Show all

Plos Pathogens | PUBLIC LIBRARY SCIENCE | Published : 2022

DOI: 10.1371/journal.ppat.1010288

Abstract

Urogenital schistosomiasis is caused by the blood fluke Schistosoma haematobium and is one of the most neglected tropical diseases worldwide, afflicting > 100 million people. It is characterised by granulomata, fibrosis and calcification in urogenital tissues, and can lead to increased susceptibility to HIV/AIDS and squamous cell carcinoma of the bladder. To complement available treatment programs and break the transmission of disease, sound knowledge and understanding of the biology and ecology of S. haematobium is required. Hybridisation/introgression events and molecular variation among members of the S. haematobium- group might effect important biological and/or disease traits as well as..

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